136995-18-1Relevant academic research and scientific papers
5-Substituted 4-isoxazolecarboxamides with platelet antiaggregating and other activities
Fossa,Menozzi,Schenone,Filipelli,Russo,Lucarelli,Marmo
, p. 789 - 802 (2007/10/02)
The synthesis of a series of 5-substituted 4-isoxazolecarboxamides by reaction of eight 5-substituted 4-isoxazolecarbonyl chlorides with pyrrolidine, piperidine, morpholine and 4-trifluoromethylaniline is described. Some of these amides showed platelet antiaggregating activity in vitro slightly inferior to that of acetylsalicylic acid, as well weak antiinflammatory, analgesic and antipyretic activities in rats and mice.
