76344-95-1

Usage

Uses

Used in Pharmaceutical Industry:
5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is used as a drug intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Agrochemical Industry:
In the agrochemical sector, 5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID serves as a building block in the creation of agrochemicals. Its incorporation can lead to the development of more effective pesticides, herbicides, and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID is utilized as a reagent in organic synthesis. Its chemical properties make it a valuable asset in the synthesis of complex organic compounds, facilitating reactions that may otherwise be challenging to achieve.
Used as a Catalyst in Chemical Reactions:
Due to its structural features, 5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID may also function as a catalyst in certain chemical reactions. Its ability to increase the rate of reactions without being consumed in the process can improve the efficiency of various chemical processes and the synthesis of new chemical entities for medicinal purposes.

InChI:InChI=1/C10H7NO3/c12-10(13)8-6-11-14-9(8)7-4-2-1-3-5-7/h1-6H,(H,12,13)

Upstream product

• 50784-69-5 5-phenyl-isoxazole-4-carboxylic acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 66129-60-0 (E)-ethyl 2-(N,N-dimethylaminomethyliden) benzoylacetate 
• 103030-37-1 4-chloromethyl-5-phenyl-isoxazole 

Downstream Products

• 136995-29-4 5-phenylisoxazole-4-carbonyl chloride 
• 1201986-70-0 C₁₁H₁₀N₂O₃ 
• 1201986-69-7 C₁₀H₆N₄O₂ 
• 136995-19-2 N-(4-trifluoromethylphenyl)-5-phenylisoxazole-4carboxamide 
• 136995-18-1 4-[(5-phenyl-4-isoxazolyl)carbonyl]-morpholine 
• 136995-17-0 1-[(5-phenyl-4-isoxazolyl)carbonyl]-piperidine 
• 502935-51-5 5-phenyl-isoxazole-4-carboxylic acid methoxy-amide 
• 1003558-68-6 N,N-Dimethyl-3-phenyl-1-[(5-phenylisoxazol-4-yl)carbonyl]pyrrolidine-3-carboxamide 
• 1027493-84-0 4-Bromomethyl-5-phenyl-isoxazole 
• 155602-43-0 5-phenyl-4-isoxazolemethanol 

Relevant academic research and scientific papers

A general and efficient PIFA mediated synthesis of heterocycle-fused quinolinone derivatives

A new application of the hypervalent iodine reagent phenyliodine(III)bis(trifluoroacetate) (PIFA) has been developed for the construction of a series of N, O, S-containing heterocycle-fused quinolinone derivatives in a general and efficient way. An altern

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with hydroxylamine hydrochloride in methanol solution afforded in high yields the relative esters of 5-substituted 4-isoxazolecarboxylic acids II.These esters were hydrolyzed generally with concentrated hydrochloric acid-acetic acid mixtures to the corresponding carboxylic acids in satisfactory yields.Ethyl or methyl esters II isomerized with sodium ethoxide or methoxide, respectively, to the corresponding esters or hemiesters of 2-cyano-3-oxoalkanoic acids generally in excellent to satisfactory yields.Reaction of methyl 5,5-dimethyl-3-dimethylaminomethylene-2,4-dioxohexanoate with hydroxylamine hydrochloride afforded in moderate yield methyl 4-(2,2-dimethyl-1-oxopropyl)-5-isoxazolecarboxylate, which was converted by acid hydrolysis as above to 4-t-butyl-4-hydroxyfuroisoxazol-6-(4H)-one.