136995-25-0

Upstream product

• 127958-23-0 methyl 2-[(dimethylamino)methylene]-4-methoxy-3-oxobutanoate 
• 41051-15-4 4-methoxyacetoacetic acid methylester 
• 134540-99-1 methyl 5-(methoxymethyl)isoxazole-4-carboxylate 
• 134541-08-5 5-(methoxymethyl)isoxazole-4-carboxylic acid 
• 455-14-1 4-trifluoromethylphenylamine 
• 136995-30-7 5-Methoxymethyl-isoxazole-4-carbonyl chloride 

Downstream Products

• 1058722-46-5 C₁₂H₉F₃N₂O₃ 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERIODONTITIS AND RHEUMATOID ARTHRITIS

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of periodontitis and rheumatoid arthritis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

5-Substituted 4-isoxazolecarboxamides with platelet antiaggregating and other activities

The synthesis of a series of 5-substituted 4-isoxazolecarboxamides by reaction of eight 5-substituted 4-isoxazolecarbonyl chlorides with pyrrolidine, piperidine, morpholine and 4-trifluoromethylaniline is described. Some of these amides showed platelet antiaggregating activity in vitro slightly inferior to that of acetylsalicylic acid, as well weak antiinflammatory, analgesic and antipyretic activities in rats and mice.