1369960-67-7Relevant academic research and scientific papers
Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states
Dayde, Benedicte,Benzaria, Samira,Pierra, Claire,Gosselin, Gilles,Surleraux, Dominique,Volle, Jean-Noel,Pirat, Jean-Luc,Virieux, David
, p. 3448 - 3454 (2012/05/31)
A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2- hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.
