137-44-0 Usage
General Description
1,3,5-Pyrazolone is a chemical compound with the molecular formula C3H4N2O. It is a heterocyclic organic compound that is commonly used as a building block for the synthesis of pharmaceuticals, agrochemicals, and dyes. 1,3,5-Pyrazolone is a white crystalline solid that is soluble in water and polar organic solvents. It is known for its ability to act as a chelating agent, forming complexes with metal ions. 1,3,5PYRAZOLONE is also used as a reagent in organic synthesis reactions, particularly in the formation of heterocyclic compounds. Additionally, 1,3,5-Pyrazolone has been studied for its potential pharmacological properties, including its anti-inflammatory and antitumor activities.
Check Digit Verification of cas no
The CAS Registry Mumber 137-44-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 137-44:
(5*1)+(4*3)+(3*7)+(2*4)+(1*4)=50
50 % 10 = 0
So 137-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H4N2O/c6-3-1-2-4-5-3/h2H,1H2,(H,5,6)
137-44-0Relevant articles and documents
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3β
Arnost, Michael,Pierce, Al,Haar, Ernst ter,Lauffer, David,Madden, Jaren,Tanner, Kirk,Green, Jeremy
scheme or table, p. 1661 - 1664 (2010/07/03)
A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3β was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.