1370037-52-7Relevant articles and documents
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases
Wang, Yue,Guan, Xin-Lei,Wu, Peng-Fei,Wang, Can-Ming,Cao, Hui,Li, Lei,Guo, Xiao-Juan,Wang, Fang,Xie, Na,Jiang, Feng-Chao,Chen, Jian-Guo
, p. 3588 - 3592 (2012)
Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed a synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, and less hepatotoxicity, emerging as promising molecules for the therapy of age-related neurodegenerative diseases.