1370293-18-7

Basic information

• Product Name: (R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(4-fluorophenyl)methanol
• Synonyms: (R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(4-fluorophenyl)methanol
• CAS NO: 1370293-18-7
• Molecular Weight: 429.915
• Mol File: 1370293-18-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(4-fluorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(4-fluorophenyl)methanol(1370293-18-7)
• EPA Substance Registry System: (R)-(1-(3-chloropropylsulfonyl)pyrrolidin-2-yl)bis(4-fluorophenyl)methanol(1370293-18-7)

Safety Data

• Hazardous Substances Data: 1370293-18-7(Hazardous Substances Data)

Upstream product

• 352-13-6 4-flourophenylmagnesium bromide 
• 1633-82-5 3-chloro-n-propanesulfonyl chloride 
• 1198225-48-7 (R)-bis(4-fluorophenyl)(pyrrolidin-2-yl)methanol 
• 1370292-91-3 (R)-ethyl 2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1370293-30-3 (R)-3-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propan-1-ol 
• 1198222-51-3 (R)-1-(3-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propyl)pyrimidine-2,4(1H,3H)-dione 
• 1370293-24-5 (R)-3-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-ylsulfonyl)propyl acetate 

Relevant articles and documents

Synthesis and discovery of N -carbonylpyrrolidine- or N -sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors

Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies of uracil derivatives. N-Carbonylpyrrolidine- and N-sulfonylpyrrolidine- containing uracils were found to be promising scaffolds that led us to human dUTPase inhibitors (12k) having excellent potencies (IC50 = 0.15 μM). The X-ray structure of a complex of 16a and human dUTPase revealed a unique binding mode wherein its uracil ring and phenyl ring occupy a uracil recognition region and a hydrophobic region, respectively, and are stacked on each other. Compounds 12a and 16a markedly enhanced the growth inhibition activity of 5-fluoro-2′-deoxyuridine against HeLa S3 cells in vitro (EC50 = 0.27-0.30 μM), suggesting that our novel dUTPase inhibitors could contribute to the development of chemotherapeutic strategies when used in combination with TS inhibitors.