1370352-22-9Relevant academic research and scientific papers
Highly enantioselective synthesis of 2,3-dihydroquinazolinones through intramolecular amidation of imines
Prakash, Muthuraj,Kesavan, Venkitasamy
, p. 1896 - 1899 (2012)
Enantioselective synthesis of 2,3-dihydroquinazolinones (DHQZs) was accomplished using readily available Sc(III)-inda-pybox as the catalyst. This is the first report on the metal catalyzed asymmetric intramolecular amidation of imines to synthesize DHQZs.
Investigation of the enantioselective synthesis of 2,3- Dihydroquinazolinones Using Sc(III)- Inda -pybox
Prakash, Muthuraj,Jayakumar, Samydurai,Kesavan, Venkitasamy
supporting information, p. 2265 - 2272 (2013/09/02)
Derivatives of 2,3-dihydroquinazolinones (2,3-DHQZs) are prized for their prevalent pharmaceutical applications. Although there are potential applications, methods available for the enantioselective synthesis of these valuable compounds are scarce, since the chiral aminal center is prone to racemization. We have overcome the difficulties in the catalytic enantioselective synthesis of 2,3-DHQZs using Sc(III)-inda-pybox as a catalyst, in a process with a broad substrate scope. Georg Thieme Verlag Stuttgart. New York.
