1370426-41-7Relevant academic research and scientific papers
Anti-Markovnikov stereoselective hydroamination and hydrothiolation of (hetero)aromatic alkynes using a metal-free cyclic trimeric phosphazene base
Zhao, Na,Lin, Chengdong,Wen, Lirong,Li, Zhibo
, p. 3432 - 3440 (2019/05/15)
Hydroamination and hydrothiolation are the most efficient and completely atom-economical process to construct important enamine and vinyl sulfide intermediates in pharmaceutical and organic chemistry. The cyclic trimeric phosphazene base (CTPB) showed gre
A stereoselective organic base-catalyzed protocol for hydroamination of alkynes under solvent-free conditions
Kozell, Vadym,Rahmani, Fariba,Piermatti, Oriana,Lanari, Daniela,Vaccaro, Luigi
, p. 188 - 191 (2018/06/26)
The hydroamination of alkynes is a straightforward and atom-economical process for the synthesis of substituted nitrogen-containing alkenes. Herein we report a novel protocol that involves for the first time solvent-free conditions (SolFC) and the use of an organic base, namely 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) to stereoselectively promote the process. The scope of this metal-free protocol has been evaluated through an extensive study that has led to the conclusion that in most cases the yield and stereoselectivity values are very high (14 examples, up to 95% yield, Z/E up to 99%).
Palladium-catalyzed oxidative intramolecular C-C bond formation via double sp2 C-H activation between the 2-position of imidazoles and a benzene ring
Sun, Manman,Wu, Huandong,Zheng, Junnan,Bao, Weiliang
supporting information; experimental part, p. 835 - 838 (2012/05/20)
Oxidative intramolecular C-C bond formation via double sp2 C-H activation between the 2-position of imidazoles and a benzene ring catalyzed by palladium(II) has been developed, which provides an atom-economical, concise and efficient methodology to synthesize imidazole- or benzimidazole-fused isoquinoline polyheteroaromatic compounds. Copyright
