1370455-89-2

Upstream product

• 1370453-12-5 N-(6-chloro-4-nitropyridin-2-yl)pyrazin-2-amine 
• 1197294-80-6 tert-butyl 4-(4-bromopyridin-2-yl)piperazine-1-carboxylate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 128071-98-7 4-bromo-2-fluoropyridine 
• 1679-64-7 Monomethyl terephthalate 
• 1370453-11-4 tert-butyl 4-[4-amino-6-(pyrazin-2-ylamino)-2,4'-bipyridin-2'-yl]piperazine-1-carboxylate 

Downstream Products

• 1370455-88-1 4-({[2'-piperazin-1-yl-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]aminol}arbonyl)benzoic acid 
• 1370455-90-5 4-({[2'-[4-(tert-butoxycarbonyl)piperazin-1-yl]-6-(pyrazin-2-ylamino)-2,4'-bipyridin-4-yl]amino}carbonyl)benzoic acid 

Relevant academic research and scientific papers

Highly potent aminopyridines as Syk kinase inhibitors

A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2- pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.

PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase and/or Janus kinases.

Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase and/or Janus kinases.