128071-98-7

Basic information

• Product Name: 4-Bromo-2-fluoropyridine
• Synonyms: -Bromo-2-fluoropyridine;4-Bromo-2-fluoropyridine ,98%;broMo-4 fluoro-2 pyridine;Pyridine,4-broMo-2-fluoro-;4-Bromo-2-fluoropyridine,95%;4-BROMO-2-FLUOROPYRIDINE;4-BROMO-2-FLUORPYRIDINE;4-BROMO-2-FLUOROPYRINE/2-FLUORO-4-BROMOPYRIDINE
• CAS NO: 128071-98-7
• Molecular Formula: C₅H₃BrFN
• Molecular Weight: 175.99
• Product Categories: Variety of halogenated heterocyclic series;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;NULL;Fluorine series;Fluorin-contained pyridine series;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines;Organohalides
• Mol File: 128071-98-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 65°C (5 mmHg
• Flash Point: 71°C
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.713g/mLat 25℃
• Vapor Pressure: 0.576mmHg at 25°C
• Refractive Index: n20/D 1.531
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Soluble), Methanol (Slightly)
• PKA: 0.81±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-2-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-fluoropyridine(128071-98-7)
• EPA Substance Registry System: 4-Bromo-2-fluoropyridine(128071-98-7)

Safety Data

• Hazard Codes: Xi,T,Xn,F
• Statements: 2237/3841-36/37/38-20/21/22-10-41-37/38-22
• Safety Statements: 2639-36-26-16-39-36/37
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 128071-98-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

Uses

4-Bromo-2-fluoropyridine is used in preparation of isoquinolinone derivatives and pharmaceutical compounds thereof for prevention or treatment of poly(ADP-ribose)polymerase-1 (PARP-1)-associated diseases.

InChI:InChI=1/C5H3BrFN/c6-4-1-2-8-5(7)3-4/h1-3H

Upstream product

• 372-48-5 2-fluoropyridine 
• 36178-05-9 3-bromo-2-fluoropyridine 

Downstream Products

• 1001077-13-9 C₉H₁₁BrN₂O₂ 
• 1010115-46-4 C₁₁H₇ClFNS 
• 1142194-24-8 4-bromo-2-(isopropoxy)pyridine 
• 850250-72-5 4-(4-bromo-2-pyridyloxy)aniline 
• 1593268-03-1 1-(2-fluoropyridin-4-yl)-3-(2-methoxyphenyl)prop-2-yn-1-one 
• 1426921-26-7 5-(2-fluoropyridin-4-yl)-2-(tetrahydropyran-4-yloxy)benzonitrile 
• 1190618-32-6 (6-chloro-benzothiazol-2-yl)-[4-(2-fluoro-pyridin-4-yl)-phenyl]-amine 
• 1187744-24-6 4-(4-chlorophenyl)-2-fluoropyridine 
• 1163707-56-9 4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine 
• 1163707-59-2 1-(4-bromo-pyridin-2-yl)-cyclobutanecarbonitrile 
• 1019918-39-8 4-bromo-2-hydrazineylpyridine 
• 863409-08-9 5-(2-fluoro-pyridin-4-yl)-thiophene-2-carboxylic acid 
• 401815-98-3 2-fluoropyridin-4-ylboronic acid 
• 458532-86-0 2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine 

Relevant articles and documents

Substituted pyridines

A class of 2,4-; 2,3,4-; 2,4,6-; 2,3,4,5,6-substituted pyridines is provided which include novel compounds. The substitutions are achieved according to methods disclosed herein in which a metallated pyridine is reacted with an electrophile. Suitable electrophiles include CO2, SO2, dialkylcarbonates, ureas, formamides, amides, carboxylic acid esters, mono- and dihaloalkyls, halogens such as chlorine, fluorine, bromine, and iodine, metallic salts, sulfones, sulfonyls, aldehydes, ketones, anhydrides, nitrites, and electrophilic boron compounds including, but not limited to, boron trialkoxides and boron trihalides. The subject invention more specifically discloses a process for the synthesis of 2,6-difluoropyridin-4-ylboronic acid which comprises: (1) reacting 2,4,6-trifluoropyridine with hydrazine monohydrate to produce 2,6-difluoro-4-hydrazinopyridine, (2) reacting the 2,6-difluoro-4-hydrazinopyridine with elemental bromine to produce 4-bromo-2,6-difluoropyridine, and (3) reacting the 4-bromo-2,6-difluoropyridine with an organolithium compound and a borate at a temperature of less than about 0° C. to produce the 2,6-difluoropyridin-4-ylboronic acid, wherein said process is conducted in an organic solvent.

Migration du lithium en serie pyridinique: double catalyse et reformage. Acces aux derives de la bromo-2 lithio-3 pyridine et des bromo-4 halogeno-2 lithio-3 pyridines

The lithium of an organolithium-pyridinic derivative can be moved from one position to an another by an intermolecular reaction.Two new reactions are possible for pyridinic organic synthesis: the isomerisation of any lithio derivative to a more stable one, and a reaction that transforms a mixture of various bromo-lithio derivatives into a single one.The processes involved and the experimental tools used are described in terms of the 2-bromo-3-lithio- and 4-bromo-2-halogeno-3-lithiopyridines derivatives synthesis.