137047-35-9

Upstream product

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 137047-33-7 1-[(E)-5-(1-Methoxy-1-methyl-ethoxy)-3-methyl-pent-3-en-1-ynyl]-2,2,6-trimethyl-cyclohexanol 
• 80713-62-8 5-(1-methoxy-1-methylethoxy)-3-methyl-3E-penten-1-yne 
• 74976-66-2 3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-yn-1-ol 
• 603-35-0 triphenylphosphine 

Relevant academic research and scientific papers

Preparation of (7Z) - and (7Z,11Z) - Vitamin A

An efficient access to (7Z)- and (7Z,11Z)-vitamin A is described. Following the addition of a C6-acetylenic building block to 2,6,6-trimethylcyclohexanone (2), dehydration of the tert. alcohol 3 and formation of the C15-Wittig salt, the (7Z)-geometry was introduced by partial hydrogenation of the triple bond over Raney-nickel. Following Wittig reaction with (E)-2-methyl-4-acetoxy-2-butenal gave a mixture of the title compounds 8 and 9 which could easily be separated.