74976-66-2

Upstream product

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 80713-62-8 5-(1-methoxy-1-methylethoxy)-3-methyl-3E-penten-1-yne 
• 185946-32-1 (E)-5-(1-Hydroxy-2,2,6-trimethyl-cyclohexyl)-3-methyl-pent-2-en-4-ynoic acid methyl ester 
• 41613-59-6 1-ethynyl-2,2,6-trimethyl-1-cyclohexanol 
• 178985-92-7 (E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-ynoic acid methyl ester 
• 137047-33-7 1-[(E)-5-(1-Methoxy-1-methyl-ethoxy)-3-methyl-pent-3-en-1-ynyl]-2,2,6-trimethyl-cyclohexanol 

Downstream Products

• 137047-35-9 [(Z)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-ynyl]-triphenyl-phosphonium; chloride 
• 100183-85-5 [(E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-pent-2-en-4-ynyl]-triphenyl-phosphonium; chloride 
• 137121-53-0 Hexadecanoic acid (2E,4E,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-54-1 Hexadecanoic acid (2E,4Z,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 137121-51-8 Acetic acid (2E,4Z,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 127-47-9 Acetic acid (2E,4E,6E,8Z)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester 
• 6018-74-2 (7Z)-Vitamin A 
• 137121-52-9 (7Z,11Z)-Vitamin A 
• 100183-86-6 [(2E,4Z)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl]-triphenyl-phosphonium; chloride 
• 137121-50-7 7-cis-retinyl acetate 
• 178985-94-9 1,3,3-Trimethyl-2-((E)-3-methyl-hex-3-ene-1,5-diynyl)-cyclohexene 
• 69037-20-3 5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-(E)-2-penten-4-yn-al 

Relevant academic research and scientific papers

Palladium-catalyzed additions of terminal alkynes to acceptor alkynes

The development of addition reactions wherein the product is the simple sum of the reactants plus anything else (only needed catalytically) constitutes an important goal for enhanced synthetic efficiency. The C-H bond of terminal alkynes (the donor alkyne

Iterative PD catalyzed additions for a synthesis of methyl 7,8,11,12 tetradehydroretinoate

A 6 step synthesis of the title compound derives from a palladium catalyzed addition of terminal alkynes to acceptor alkynes.

Preparation of (7Z) - and (7Z,11Z) - Vitamin A

An efficient access to (7Z)- and (7Z,11Z)-vitamin A is described. Following the addition of a C6-acetylenic building block to 2,6,6-trimethylcyclohexanone (2), dehydration of the tert. alcohol 3 and formation of the C15-Wittig salt, the (7Z)-geometry was introduced by partial hydrogenation of the triple bond over Raney-nickel. Following Wittig reaction with (E)-2-methyl-4-acetoxy-2-butenal gave a mixture of the title compounds 8 and 9 which could easily be separated.