1370471-83-2

Upstream product

• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 119072-55-8 tert-butylisonitrile 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 71387-23-0 4-(prop-2-yn-1-yl 2-oxo-2H-chromene-3-carboxylate) 
• 1370471-46-7 C₂₁H₂₅N₅O₂ 
• 1370472-34-6 N-benzyl-N-(2-(tert-butylamino)-2-oxo-1-phenylethyl)-2-chloroacetamide 

Relevant academic research and scientific papers

Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi-Mannich triazole randomization using copper catalyzed alkyne azide click chemistry

An efficient synthesis of ester-triazole-amide amphiphiles of coumarin derivatives by triazole randomization based on click approach is described. Twenty-five small peptide azides were synthesized using Ugi or alternate Mannich-type multi-component reactions. The new azides were then used for the triazole randomization of alkyne functionalized coumarin ester under CuAAC conditions. Sixty-five new peptide bio-hybrids are obtained in near quantitative yield with high regio and stereoselectivity.