1370519-53-1

Basic information

• Product Name: (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one
• Synonyms: (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one
• CAS NO: 1370519-53-1
• Molecular Weight: 407.447
• Mol File: 1370519-53-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one(1370519-53-1)
• EPA Substance Registry System: (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one(1370519-53-1)

Safety Data

• Hazardous Substances Data: 1370519-53-1(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 6099-27-0 2-(benzylsulfonyl)-1-phenylethanone 
• 552-89-6 2-nitro-benzaldehyde 
• 2408-88-0 2-benzylsulfanyl-1-phenylethanone 

Relevant articles and documents

Design, synthesis and biological evaluation of novel (E)-α- benzylsulfonyl chalcone derivatives as potential BRAF inhibitors

Activating mutations in the BRAF serine/threonine kinase are found in more than 70% of human melanomas, >90% of which are BRAFV600E. It provides new therapeutic opportunities in malignant melanoma. In silico and in vitro screening of our compound collection has identified Hit 2 as BRAF V600E inhibitor. Based on its structure, a series of novel (E)-α-benzylsulfonyl chalcone derivatives (13-40) were designed and synthesized. Compound 38 exhibited the most potent inhibitory activity with an IC50 value of 0.17 μM for BRAFV600E and GI50 value of 0.52 μM for mutant BRAF-dependent cells. The results of cell based pERK activity and cellular selectivity suggested that those compounds could selectively inhibit proliferation of mutant BRAF-dependent melanoma cell line through inhibition of oncogenic BRAF.