6099-27-0

Basic information

• Product Name: 2-(benzylsulfonyl)-1-phenylethanone
• CAS NO: 6099-27-0
• Molecular Formula: C₁₅H₁₄O₃S
• Molecular Weight: 274.3349
• Mol File: 6099-27-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 507.1°C at 760 mmHg
• Flash Point: 332°C
• Density: 1.251g/cm³
• Vapor Pressure: 2.09E-10mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-(benzylsulfonyl)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzylsulfonyl)-1-phenylethanone(6099-27-0)
• EPA Substance Registry System: 2-(benzylsulfonyl)-1-phenylethanone(6099-27-0)

Safety Data

• Hazardous Substances Data: 6099-27-0(Hazardous Substances Data)

Usage

General Description

2-(benzylsulfonyl)-1-phenylethanone is a chemical compound that belongs to the class of aromatic ketones. It is a crystalline solid with a molecular formula of C16H14O3S and a molecular weight of 294.35 g/mol. 2-(benzylsulfonyl)-1-phenylethanone is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic synthesis and as a building block for the preparation of more complex molecules. Additionally, it has been studied for its potential biological activities and pharmacological properties. Overall, 2-(benzylsulfonyl)-1-phenylethanone plays a crucial role in the field of organic chemistry and drug development, making it a valuable and versatile chemical compound.

Upstream product

• 100-53-8 phenylmethanethiol 
• 28203-59-0 (benzylsulfonyl)acetic acid 
• 98-88-4 benzoyl chloride 
• 177703-80-9 2-phenylmethanesulfonylacetonitrile 
• 98-80-6 phenylboronic acid 
• 70-11-1 α-bromoacetophenone 
• 51793-64-7 sodium α-toluenesulfinate 
• 61821-05-4 α-benzoyl-α-(benzylsulfonyl)diazomethane 
• 100-51-6 benzyl alcohol 
• 2408-88-0 2-benzylsulfanyl-1-phenylethanone 

Downstream Products

• 3112-90-1 benzyl-methyl sulfone 
• 65-85-0 benzoic acid 
• 1370519-53-1 (E)-2-(benzylsulfonyl)-3-(2-nitrophenyl)-1-phenylprop-2-en-1-one 
• 1370519-50-8 (E)-2-(benzylsulfonyl)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 1370519-49-5 (E)-2-(benzylsulfonyl)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 115351-24-1 (E)-2-(benzylsulfonyl)-3-(2-chlorophenyl)-1-phenylprop-2-en-1-one 
• 1370519-51-9 (E)-2-(benzylsulfonyl)-3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 115351-23-0 (E)-2-(benzylsulfonyl)-3-(4-fluorophenyl)-1-phenylprop-2-en-1-one 
• 1370519-52-0 (E)-2-(benzylsulfonyl)-1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one 
• 61821-18-9 2-Ethoxy-1-phenyl-2-phenylmethanesulfonyl-ethanone 
• 60279-05-2 2-Methoxy-1-phenyl-2-phenylmethanesulfonyl-ethanone 
• 61821-05-4 α-benzoyl-α-(benzylsulfonyl)diazomethane 

Relevant articles and documents

One-pot synthesis of β-keto sulfones by the condensative decarboxylation of sulfonylacetic acids with acid chlorides under mild conditions

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Rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/ arylsulfonyl)acetonitriles: Efficient synthesis of (Z)-β- sulfonylvinylamines and β-Keto sulfones

An efficient rhodium(I)-catalyzed addition of arylboronic acids to (benzyl-/arylsulfonyl)acetonitrile is described. Novel β-sulfonylvinylamine products are formed in a stereoselective fashion (Z-alkene). Upon hydrolysis, useful β-keto sulfones are obtained with a broad scope of aryl and sulfonyl substituents.

α-Fluorination of β-ketosulfones by Selectfluor F-TEDA-BF4

Attempted fluorination of β-ketosulfides using Selectfluor resulted only in the isolation of the corresponding diaryl disulfides, presumed to arise by decomposition of an unstable fluorinated intermediate. However, fluorination of β-ketosulfones using Selectfluor under anhydrous conditions does allow the isolation of both mono-and difluorinated products in moderate to good yields.