1370528-53-2Relevant academic research and scientific papers
Synthesis of 2-Iminoindolines via samarium diiodide mediated reductive cyclization of carbodiimides
Ishida, Takayuki,Tsukano, Chihiro,Takemoto, Yoshiji
, p. 44 - 46 (2012/03/09)
A method of synthesizing 2-iminoindolines using samarium diiodide (SmI 2) is reported. In the presence of tert-butyl alcohol, treatment of carbodiimides bearing α,β-unsaturated carbonyl moieties with a stoichiometric amount of SmI2 afforded 2- iminoindolines in moderate to high yields. The products were isolated after Boc protection of the amidine moieties. This reaction proved to be applicable to lactams and acyclic/cyclic esters as substrates.
