1370554-88-3Relevant academic research and scientific papers
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53
Wilcken, Rainer,Liu, Xiangrui,Zimmermann, Markus O.,Rutherford, Trevor J.,Fersht, Alan R.,Joerger, Andreas C.,Boeckler, Frank M.
, p. 6810 - 6818 (2012)
The destabilizing p53 cancer mutation Y220C creates a druggable surface crevice. We developed a strategy exploiting halogen bonding for lead discovery to stabilize the mutant with small molecules. We designed halogen-enriched fragment libraries (HEFLibs)
