1370554-89-4Relevant academic research and scientific papers
COMPOUNDS FOR USE IN STABILISING p53 MUTANTS
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, (2013/02/28)
Provided are compounds for use in a method of treatment of a subject who has a lesion or a tumour in which p53 carries a Y220C mutation, in which the compound is selected from compounds of the following formula (I), and pharmaceutically acceptable salts,
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53
Wilcken, Rainer,Liu, Xiangrui,Zimmermann, Markus O.,Rutherford, Trevor J.,Fersht, Alan R.,Joerger, Andreas C.,Boeckler, Frank M.
scheme or table, p. 6810 - 6818 (2012/06/15)
The destabilizing p53 cancer mutation Y220C creates a druggable surface crevice. We developed a strategy exploiting halogen bonding for lead discovery to stabilize the mutant with small molecules. We designed halogen-enriched fragment libraries (HEFLibs)
