1370587-84-0Relevant articles and documents
Alkyne and reversible nitrile activation: N, N'-diamidocarbene-facilitated synthesis of cyclopropenes, cyclopropenones, and azirines
Moerdyk, Jonathan P.,Bielawski, Christopher W.
, p. 6116 - 6119 (2012/05/07)
We report the synthesis of a variety of diamidocyclopropenes by combining an isolable and readily accessible N,N'-diamidocarbene (DAC) with a range of alkynes (nine examples, 68-97% yield). Subsequent hydrolysis of selected cyclopropenes afforded the corresponding cyclopropenones or α,β- unsaturated acids, depending on the reaction conditions. In addition, the combination of a DAC with alkyl or aryl nitriles was found to form 2H-azirines in a reversible manner (four examples, Keq = 4-72 M-1 at 30 °C in toluene).