1370641-58-9

Basic information

• Product Name: 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one
• Synonyms: 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one
• CAS NO: 1370641-58-9
• Molecular Weight: 356.242
• Mol File: 1370641-58-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one(1370641-58-9)
• EPA Substance Registry System: 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one(1370641-58-9)

Safety Data

• Hazardous Substances Data: 1370641-58-9(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 1441-85-6 2-(chloroseleno)benzoyl chloride 
• 33621-60-2 2-amino-5-(4-methylphenyl)-1,3,4-oxadiazole 
• 120445-48-9 4-methylbenzaldehyde semicarbazone 

Relevant articles and documents

Synthesis and in vitro antitumor activity of 1,3,4-oxadiazole derivatives based on benzisoselenazolone

A series of novel 1,3,4-oxadiazole derivatives based on benzisoselenazolone has been prepared and tested for antiproliferative activity in vitro against the cells of human cancer cell lines: SSMC-7721 (human liver cancer cell), MCF-7 (human breast cancer cell) and A549 (human lung cancer cell). All the compounds obtained exhibited antiproliferative activity and showed selective cytotoxicity against different cancer cells. Compounds 7d and 7i showed significant antiproliferative activities against MCF-7 cells, with IC50 values of 1.07 and 1.76/μM respectively. Compound 7d were found to be the most potent compound against SSMC-7721 cells, with IC50 values 4.46/μM.