1370649-65-2Relevant academic research and scientific papers
Synthesis of some new 2-Oxo-N-[(10H-phenothiazin-10-yl)alkyl] derivatives of azetidine-1-carboxamides
Sharma, Ritu,Samadhiya, Pushkal,Srivastava,Srivastava
experimental part, p. 514 - 521 (2012/05/04)
The synthesis of a new series of 4-aryl-3-chloro-2-oxo-N-[3-(10H- phenothiazin-10-yl)propyl]azetidine-1-carboxamides, 4a-4m, is described. Phenothiazine on reaction with Cl(CH2)3Br at room temperature gave 10-(3-chloropropyl)-10H-phenothiazine (1), and the latter reacted with urea to yield 1-[3-(10H-phenothiazin-10-yl)propyl]urea (2). Further reaction of 2 with several substituted aromatic aldehydes led to N-(arylmethylidene)-N′-[3-(phenothiazin-10-yl)propyl]ureas 3a-3m, which, on treatment with ClCH2COCl in the presence of Et3N, furnished the desired racemic trans-2-oxoazetidin-1-carboxamide derivatives 4a-4m. The structures of all new compounds were confirmed by IR, and 1H- and 13C-NMR spectroscopy, FAB mass spectrometry, and chemical methods. Copyright
Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine
Sharma, Ritu,Samadhiya, Pushkal,Srivastava, Savitri D.,Srivastava, Santosh K.
experimental part, p. 17 - 26 (2012/05/05)
A new series of N-[3-(10H-phenothiazin-10-yl)propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-3-thiazolidinecarboxamide, 5a-s were synthesized. The reaction of thioglycolic acid with N-[3-(10H-phenothiazin- 10-yl)propyl]-N'-[(substituted phenyl)methylidene]urea, 3a-s in the presence of anhydrous ZnCl2 afforded the new heterocyclic compounds N-[3- -(10H-phenothiazin-10-yl)propyl]-2-(substituted phenyl)-4-oxo-3- thiazolidinecarboxamide, 4a-s. The latter product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa underwent the Knoevenagel reaction to yield 5a-s. The structure of compounds 1, 2, 3a-s, 4a-s and 5a-s were confirmed by IR, 1H-NMR, 13C-NMR and FAB mass spectroscopy and by chemical analysis. All the above compounds were screened for their antimicrobial activity against some selected bacteria and fungi and for their antituberculosis activity, the compounds were screened against the bacterium Mycobacterium tuberculosis. Copyright 2012 (CC) SCS.
