1370655-22-3Relevant academic research and scientific papers
Stereoselective synthesis of the C5-C18 fragment of halichomycin
Li, Qingjiang,Mao, Shiyong,Cui, Yuxin,Jia, Yanxing
, p. 4111 - 4116 (2012)
An efficient and convergent synthesis of the C5-C18 fragment of halichomycin is reported. Butanolide fragment 6 was readily prepared stereoselectively from (R)-Roche ester through catalyst control; dienylic bromide domain 7 was synthesized from (S)-serine by substrate control. C 5-C18 fragment 2 was rapidly assembled through a stereoselective alkylation of the butanolide with the dienylic bromide, followed by functional group transformations.
