1370699-05-0

Basic information

• Product Name: benzo[1,3]dioxole-5-carboxylic acid [3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylamino)phenyl]amide
• CAS NO: 1370699-05-0
• Molecular Weight: 468.53
• Mol File: 1370699-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzo[1,3]dioxole-5-carboxylic acid [3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylamino)phenyl]amide(CAS DataBase Reference)
• NIST Chemistry Reference: benzo[1,3]dioxole-5-carboxylic acid [3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylamino)phenyl]amide(1370699-05-0)
• EPA Substance Registry System: benzo[1,3]dioxole-5-carboxylic acid [3-(2,5-dimethylbenzyloxy)-4-(methanesulfonylamino)phenyl]amide(1370699-05-0)

Safety Data

• Hazardous Substances Data: 1370699-05-0(Hazardous Substances Data)

Upstream product

• 121-88-0 5-Nitro-2-aminophenol 
• 50837-53-1 2,5-dimethylbenzyl bromide 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 1334289-37-0 C₁₆H₂₀N₂O₃S 
• 930797-71-0 N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide 
• 930797-62-9 2-(2,5-dimethylbenzyloxy)-4-nitroaniline 

Downstream Products

• 1370699-06-1 benzo[1,3]dioxole-5-carboxylic acid {3-(2,5-dimethylbenzyloxy)-4-[(6-hydroxyhexyl)methanesulfonylamino]phenyl}amide 

Relevant articles and documents

Identification of a class of novel tubulin inhibitors

We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. However, the molecular targets of these agents still remain unclear. In this study, we synthesized a biotinylated probe based on a representative molecule of the compound library and performed protein pull-down assays to purify the anticancer targets of the compound. Via proteomic approaches, the major proteins bound to the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibited tubulin polymerization by binding at the colchicine domain. However, the tubulin inhibitory effect of the compound activated the Hsp27 phosphorylation and possibly overrode the direct Hsp27 inhibitory effects, which made it difficult to solely validate the Hsp27 target. Taken together, the compound was a dual ligand of tubulin and Hsp27, inhibited tubulin polymerization, and had the potential to be a class of new chemotherapeutic agents.