930797-62-9

Upstream product

• 121-88-0 5-Nitro-2-aminophenol 
• 50837-53-1 2,5-dimethylbenzyl bromide 

Downstream Products

• 1021926-24-8 C₁₇H₂₀N₂O₇S₂ 
• 930797-71-0 N-[2-(3',6'-dimethyI-benzyloxy)-4-nitrophenyl]-methanesulfonamide 
• 1334289-39-2 C₂₉H₄₂N₂O₄S 
• 1334289-40-5 C₂₈H₄₀N₂O₆S 
• 1334289-41-6 C₂₉H₄₂N₂O₅S 
• 1334289-42-7 C₂₉H₄₃N₃O₄S 
• 1334289-43-8 C₃₅H₅₃N₃O₅S 
• 1334289-44-9 C₄₀H₄₉N₃O₅S 
• 1334289-37-0 C₁₆H₂₀N₂O₃S 
• 1334289-38-1 C₂₃H₃₀N₂O₄S 
• 1445997-12-5 N-[4-amino-2-(2,5-dimethylbenzyloxy)phenyl]-N-methyltrifluoromethanesulfonamide 
• 1445997-10-3 N-methyl-N-[2-(2,5-dimethylbenzyloxy)-4-nitrophenyl]trifluoromethanesulfonamide 
• 1445997-08-9 N-[3-(2,5-dimethylbenzyloxy)-4-(methyl(trifluoromethylsulfonyl)amino)phenyl]-1,3-benzodioxole-5-carboxamide 
• 1445997-07-8 N-[3-(2,5-dimethylbenzyloxy)-4-(methyl(trifluoromethylsulfonyl)amino)phenyl]-2-naphthalenecarboxamide 

Relevant academic research and scientific papers

Synthesis and anticancer mechanism investigation of dual Hsp27 and tubulin inhibitors

Heat shock protein 27 (Hsp27) is a chaperone protein, and its expression is increased in response to various stress stimuli including anticancer chemotherapy, which allows the cells to survive and causes drug resistance. We previously identified lead comp

Identification of a class of novel tubulin inhibitors

We previously developed a series of anticancer agents based on cyclooxygenase-2 (COX-2) inhibitor nimesulide as a lead compound. However, the molecular targets of these agents still remain unclear. In this study, we synthesized a biotinylated probe based on a representative molecule of the compound library and performed protein pull-down assays to purify the anticancer targets of the compound. Via proteomic approaches, the major proteins bound to the probe were identified to be tubulin and heat shock protein 27 (Hsp27), and the compound inhibited tubulin polymerization by binding at the colchicine domain. However, the tubulin inhibitory effect of the compound activated the Hsp27 phosphorylation and possibly overrode the direct Hsp27 inhibitory effects, which made it difficult to solely validate the Hsp27 target. Taken together, the compound was a dual ligand of tubulin and Hsp27, inhibited tubulin polymerization, and had the potential to be a class of new chemotherapeutic agents.

Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76

JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still

Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells

A series of COX-2 selective inhibitor nimesulide derivatives were synthesized. Their anti-cell proliferation activities were evaluated with a long-term estrogen deprived MCF-7aro (LTEDaro) breast cancer cell line, which is the biological model of aromatas

SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS

Compounds and methods suppressing aromatase activity expression in cancer cells. Provided are compounds are those of formula I: wherein R1 may be alkyl, cycloakyl, haloalkyl, aryl, substituted aryl, haloaryl, alkoxy, alkylaryl, and arylalkyl; R2 is H, alk