1370701-89-5Relevant academic research and scientific papers
Divergent synthesis of novel dienylbenzothiazoles and arylidenedibenzoxazepines and evaluation of their antiproliferative and cytotoxic properties
Kathiravan,Muthukumaran,Dhatchanamoorthy,Shanmuganathan,Venugopal
, p. 314 - 322 (2018/04/20)
Background: Dibenzo-oxazepine and Benzothiazole derivatives are used as antipsychotics, anticancer, antibacterial and anti-inflammatory agents. Methods: Arylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine and 2-[2-Chloro-Cyclohex-1-enyl]- Benzothiazoles were synthesized by reacting benzylidene derivative of chloroaldehyde with 2-aminophenol and 2-aminothiophenol respectively. Benzylidene derivative of chloroaldehyde was prepared by Vilsmeier reaction of 2-benzylidenecyclohexanone derivatives, which were obtained from the condensation of various aromatic aldehydes with cyclohexanone. Results: Benzylidene derivatives of 1,2,3,4-Tetrahydro-Dibenzo[b,f][1,4]Oxazepine 6a-g exhibited promising antiproliferative activity with GI50 values in the micromolar range. The compounds containing halo, alkyl and alkoxyl groups as substituents on the benzylidine ring have been found to be very effective cytotoxic agents. Conclusion: This study identified dibenzo-oxapine as a prospective pharmacophore which set the stage for thorough exploration of this compound class as cytotoxic agents.
Direct vinylogous aldol reaction triggered by tetrabutylammonium fluoride: A highly regioselective and diastereoselective addition of cyclic β-haloenals to aromatic aldehydes
Zhang, Jingli,Gu, Lianghu,Gong, Yuefa
supporting information; experimental part, p. 468 - 472 (2012/03/11)
A new type of direct vinylogous aldol addition between cyclic β-haloenals and aromatic aldehydes promoted by TBAF has been developed. The reaction was carried out under mild conditions to provide highly functionalized δ-hydroxy-β-halo-α,β-unsaturated aldehydes with high diastereomeric ratios and low to good yields. Georg Thieme Verlag Stuttgart · New York.
