137076-50-7

Basic information

• Product Name: 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
• Synonyms: 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane;DOTAET;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7,10-tetraethyl ester
• CAS NO: 137076-50-7
• Molecular Formula: C24H44N4O8
• Molecular Weight: 516.63
• Mol File: 137076-50-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 569.7°Cat760mmHg
• Flash Point: 298.3°C
• Appearance: /
• Density: 1.091g/cm³
• Vapor Pressure: 5.45E-13mmHg at 25°C
• Refractive Index: 1.472
• Sensitive: Hygroscopic
• CAS DataBase Reference: 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane(137076-50-7)
• EPA Substance Registry System: 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane(137076-50-7)

Safety Data

• Hazardous Substances Data: 137076-50-7(Hazardous Substances Data)

Usage

General Description

1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane, also known as TEC cyclen, is a chemical compound used in various applications including medicine and industry. It belongs to the family of macrocyclic compounds and is commonly used as a chelating agent to bind and remove metal ions from solutions. TEC cyclen has a high affinity for certain metals such as copper and can be used in the treatment of heavy metal poisoning. In addition, it is also used in the synthesis of radioactive metal chelates for imaging and diagnostic purposes in medicine. The compound's chemical structure allows for strong coordination with metal ions, making it a versatile and useful chemical in a variety of fields.

InChI:InChI=1/C24H44N4O8/c1-5-33-21(29)17-25-9-11-26(18-22(30)34-6-2)13-15-28(20-24(32)36-8-4)16-14-27(12-10-25)19-23(31)35-7-3/h5-20H2,1-4H3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Downstream Products

• 60239-18-1 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 

Relevant articles and documents

Compositions for protecting skin

The purpose of the present invention is to provide a skin outer layer composition which does not have or has very low skin irritation or toxicity, and has a high ability to remove formaldehyde and heavy metals compared to conventional material. The present invention provides the skin outer layer composition comprising, as active ingredients, one or more selected from trientine or trientine derivatives represented by chemical formula 1, cyclen or cyclen derivatives represented by chemical formula 2, and cyclam or cyclam derivatives represented by chemical formula 3. In the above formulas, R_1, R_2, R_3, R_4, R_5 and R_6 are each independently hydrogen, -R_7-COOH or salts thereof, and R_7 is a C_1-C_5 aliphatic group, a substituted or unsubstituted aromatic group, or a heterocyclic six-membered or five-membered ring.COPYRIGHT KIPO 2018

A convenient, novel approach for the synthesis of polyaza macrocyclic bifunctional chelating agents

The convenient synthetically useful bifunctional chelating agents, (10-p-aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (p-ABz-DO3A) 3 and (11-p-aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-triacetate (p-ABz-TE3A) 6, were obtained by reaction of an ethyl bromoacetate with 1,4,7,10-tetraazacyclododecane and 1,4,8,11-tetraazacyclotetradecane followed by reaction with nitrobenzyl bromide. This method proved more efficient than any described in the literature since the overall yield in a two-step synthesis sequence starting from tetraazamacrocycles was 68%.