1370794-47-0

Basic information

• Product Name: (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
• Synonyms: (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
• CAS NO: 1370794-47-0
• Molecular Weight: 269.266
• Mol File: 1370794-47-0.mol

Chemical Properties

• CAS DataBase Reference: (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol(1370794-47-0)
• EPA Substance Registry System: (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol(1370794-47-0)

Safety Data

• Hazardous Substances Data: 1370794-47-0(Hazardous Substances Data)

Upstream product

• 6746-94-7 Cyclopropylacetylene 
• 205756-35-0 1-(2-amino-5-methylphenyl)-2,2,2-trifluoroethanone 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS

A process for the synthesis of chiral propargylic alcohols.

PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES

The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C2-5-alkyl C2-5-carboxylates and mixtures of at least one C2-5-alkyl C2-5-carboxylate with at least one C5-8-alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.

PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES

The invention is directed to a process for the preparation of a cyclic carbamate starting with o-aminobenzyl alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C2-5-alkyl C2-5-carboxylates and mixtures of at least one C2-5-alkyl C2-5-carboxylate with at least one C5-8-alkane.