205756-35-0

Basic information

• Product Name: Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI)
• Synonyms: Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI);1 - (2 - AMino - 5 - Methylphenyl) - 2,2,2 - trifluoroethanone;1-(2-Amino-5-methylphenyl)-2,2,2-trifluoroethan-1-one, 4-Methyl-2-(trifluoroacetyl)aniline;2'-Amino-5'-methyl-2,2,2-trifluoroacetophenone
• CAS NO: 205756-35-0
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 203.1611296
• Product Categories: ACETYLHALIDE
• Mol File: 205756-35-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI)(205756-35-0)
• EPA Substance Registry System: Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI)(205756-35-0)

Safety Data

• Hazardous Substances Data: 205756-35-0(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-amino-5-methylphenyl)-2,2,2-trifluoro- (9CI) is an organic compound with the molecular formula C10H10F3NO. It is a trifluoromethyl ketone with a substituted amino group and a methylphenyl group. This chemical compound is used in various industries, including pharmaceuticals and agrochemicals. It is a versatile intermediate in organic synthesis and can be used in the development of new drugs and crop protection agents. The trifluoromethyl group is known for its unique properties and is often used in medicinal chemistry to enhance the activity and pharmacokinetics of potential drug candidates.

Upstream product

• 106-49-0 p-toluidine 
• 21354-40-5 2,2-dimethyl-N-(4-methylphenyl)propanamide 
• 205756-33-8 N-(2-iodo-4-methylphenyl)pivalamide 
• 29289-13-2 2-iodo-4-methylaniline 
• 205756-34-9 2,2-Dimethyl-N-[4-methyl-2-(2,2,2-trifluoro-acetyl)-phenyl]-propionamide 

Downstream Products

• 1370794-47-0 (2S)-2-(2-amino-5-methylphenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol 

Relevant articles and documents

Benzylidene succinimides as 3C synthons for the asymmetric tandem Mannich reaction/transamidation of cyclic trifluoromethyl ketimines to obtain F3C-containing polycyclic dihydroquinazolinones

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethylN-acyl ketimines. Using aCinchonaalkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20?:?1 dr, up to 99% ee).

Phosphine-Catalyzed Intermolecular Annulations of Fluorinated ortho-Aminophenones with Alkynones – The Switchable [4+2] or [4+2]/[3+2] Cycloaddition

A phosphine-catalyzed intermolecular annulation reaction of functionalized ortho-aminoacetophenones with alkynones has been disclosed in this paper. A variety of 2-alkynylquinolines and benzo-fused indolizine were selectively afforded in moderate to good yields at different reaction temperatures and with different phosphine catalysts via the in situ generated zwitterionic intermediate derived from alkynone and phosphine. (Figure presented.).

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA(TM)) as HIV-1 reverse transcriptase inhibitors

Efavirenz (SUSTIVA(TM)) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse transcriptase enzyme during Efavirenz therapy, we sought to develop an optimized second generation series. To that end, SAR of the substituents on the aromatic ring was undertaken and the results are summarized here. The 5,6-difluoro (4f) and the 6-methoxy (4m) substituted benzoxazinones were determined to be equipotent, and as a result such substitution patterns will be incorporated in second generation scaffolds.