137104-41-7

Basic information

• Product Name: methyl (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoate
• Synonyms: methyl (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoate
• CAS NO: 137104-41-7
• Molecular Weight: 297.354
• Mol File: 137104-41-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoate(137104-41-7)
• EPA Substance Registry System: methyl (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoate(137104-41-7)

Safety Data

• Hazardous Substances Data: 137104-41-7(Hazardous Substances Data)

Upstream product

• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 104-94-9 4-methoxy-aniline 
• 103669-71-2 (Z)-methyl 2-(bromomethyl)-3-phenylacrylate 

Downstream Products

• 137104-69-9 (E)-3-benzylidene-1-(4-methoxyphenyl)azetidin-2-one 
• 450416-56-5 (S)-2-{(2S,3S)-2-Hydroxy-3-[((E)-2-methoxycarbonyl-3-phenyl-allyl)-(4-methoxy-phenyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 476167-89-2 (E)-2-({(4-Methoxy-phenyl)-[(E)-(3-phenyl-acryloyl)]-amino}-methyl)-3-phenyl-acrylic acid methyl ester 
• 137104-59-7 (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoic acid 
• 450416-57-6 (S)-2-{(2S,3S)-3-[((E)-2-Allyloxycarbonyl-3-phenyl-allyl)-(4-methoxy-phenyl)-amino]-2-hydroxy-3-phenyl-propionylamino}-4-methyl-pentanoic acid allyl ester 
• 476167-92-7 (S)-2-[(E)-2-({(4-Methoxy-phenyl)-[(E)-(3-phenyl-acryloyl)]-amino}-methyl)-3-phenyl-acryloylamino]-4-methyl-pentanoic acid methyl ester 

Relevant articles and documents

Cerium(IV) ammonium nitrate catalyzed synthesis of α-dehydro-β-amino esters

α-Dehydro-β-amino esters have been synthesized regioselectively from acetates of Baylis-Hillman adducts with amines in the presence of a catalytic amount of ceric ammonium nitrate (CAN) in good yield. The regioselectivity does not differ with respect to t

Palladium(0)-catalyzed regioselective synthesis of α-dehydro-β-amino esters from amines and allyl acetates: Synthesis of a α-dehydro-β-amino acid derived cyclic peptide as a constrained β-turn mimic

Acetates derived from the adducts of the Baylis-Hillman reaction can be reacted in a regioselective manner with amines in the presence of palladium(0) catalyst to afford α-dehydro-β-amino esters (2 and 3) in good yields. The regioselectivity of the reaction can be controlled by temperature and reaction medium leading to the synthesis of regioisomers 2 or 3. The α-dehydro-β-amino acid 3 is a turn inducer, and the dipeptides 6 derived from it show the presence of an eight-membered intramolecular hydrogen bond. Also, cobalt(II) chloride catalyzes the cleavage of epoxy peptides with α-dehydro-β-amino acid derivative 3b to afford the corresponding dipeptide derivatives 8, which exhibit an intramolecular hydrogen bond and thus mimic a β-turn. This intramolecular hydrogen bonding preorganizes the corresponding diallylated peptide 8c for cyclization via ring-closing metathesis to afford the cyclic peptide 9 as a constrained mimic of a β-turn.

α-methylidene- and α-alkylidene-β-lactams from nonproteinogenic amino acids

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