137104-41-7

Upstream product

• 104-94-9 4-methoxy-aniline 
• 103669-71-2 (Z)-methyl 2-(bromomethyl)-3-phenylacrylate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 

Downstream Products

• 476167-89-2 (E)-2-({(4-Methoxy-phenyl)-[(E)-(3-phenyl-acryloyl)]-amino}-methyl)-3-phenyl-acrylic acid methyl ester 
• 450416-56-5 (S)-2-{(2S,3S)-2-Hydroxy-3-[((E)-2-methoxycarbonyl-3-phenyl-allyl)-(4-methoxy-phenyl)-amino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid methyl ester 
• 137104-69-9 (E)-3-benzylidene-1-(4-methoxyphenyl)azetidin-2-one 
• 450416-57-6 (S)-2-{(2S,3S)-3-[((E)-2-Allyloxycarbonyl-3-phenyl-allyl)-(4-methoxy-phenyl)-amino]-2-hydroxy-3-phenyl-propionylamino}-4-methyl-pentanoic acid allyl ester 
• 476167-92-7 (S)-2-[(E)-2-({(4-Methoxy-phenyl)-[(E)-(3-phenyl-acryloyl)]-amino}-methyl)-3-phenyl-acryloylamino]-4-methyl-pentanoic acid methyl ester 
• 137104-59-7 (E)-2-<<(4-methoxyphenyl)amino>methyl>-3-phenylprop-2-enoic acid 

Relevant academic research and scientific papers

Cerium(IV) ammonium nitrate catalyzed synthesis of α-dehydro-β-amino esters

α-Dehydro-β-amino esters have been synthesized regioselectively from acetates of Baylis-Hillman adducts with amines in the presence of a catalytic amount of ceric ammonium nitrate (CAN) in good yield. The regioselectivity does not differ with respect to t

Synthesis of β-amino esters by regioselective amination of allyl bromides with aryl and alkyl amines

One of the two possible regioisomers can be exclusively formed by combining a suitable solvent and a specific amount of triethylamine as a base during the amination of allyl bromide 5. The SN2′ product 7 was produced using dichloromethane as a

Palladium(0)-catalyzed regioselective synthesis of α-dehydro-β-amino esters from amines and allyl acetates: Synthesis of a α-dehydro-β-amino acid derived cyclic peptide as a constrained β-turn mimic

Acetates derived from the adducts of the Baylis-Hillman reaction can be reacted in a regioselective manner with amines in the presence of palladium(0) catalyst to afford α-dehydro-β-amino esters (2 and 3) in good yields. The regioselectivity of the reaction can be controlled by temperature and reaction medium leading to the synthesis of regioisomers 2 or 3. The α-dehydro-β-amino acid 3 is a turn inducer, and the dipeptides 6 derived from it show the presence of an eight-membered intramolecular hydrogen bond. Also, cobalt(II) chloride catalyzes the cleavage of epoxy peptides with α-dehydro-β-amino acid derivative 3b to afford the corresponding dipeptide derivatives 8, which exhibit an intramolecular hydrogen bond and thus mimic a β-turn. This intramolecular hydrogen bonding preorganizes the corresponding diallylated peptide 8c for cyclization via ring-closing metathesis to afford the cyclic peptide 9 as a constrained mimic of a β-turn.

α-Dehydro β-amino acid derivatives as turn inducer: Synthesis of potential HIV protease inhibitors based on structural mimicry

α-Dehydro β-amino acid derivatives derived di- and tripeptides 4-7 adopt eight-member turn conformations in CDCl3 solutions. These peptides show similar hydrogen bonding characterstics as compared to the corresponding L-proline containing pepti

115. α-Methylidene-and α-alkylidene-β-lactams from nonproteinogenic amino acids

Treatment of methyl 2-(l-hydroxyalkyl)prop-2-enoates1 with conc. HBr solution afforded methyl (Z)-2-(bromomethyl)alk-2-enoates 2, which were transformed regioselectively into N-substituted methyl (E)-2-(aminomethyl)alk-2-enoates 3 (SN2 reaction