137104-69-9Relevant academic research and scientific papers
Ir-Catalyzed Asymmetric Hydrogenation of α-Alkylidene β-Lactams and Cyclobutanones
Xia, Jingzhao,Nie, Yu,Yang, Guoqiang,Liu, Yangang,Gridnev, Ilya D.,Zhang, Wanbin
, p. 612 - 618 (2018/06/22)
Chiral β-lactams and cyclobutanones are present in numerous natural and pharmaceutical products. The stereoselective construction of chiral four-membered cyclic compounds is an ongoing challenge for the chemical community. Herein, we report a highly stere
115. α-Methylidene-and α-alkylidene-β-lactams from nonproteinogenic amino acids
Buchholz, Rainer,Hoffmann, H. Martin R.
, p. 1213 - 1220 (2015/01/08)
Treatment of methyl 2-(l-hydroxyalkyl)prop-2-enoates1 with conc. HBr solution afforded methyl (Z)-2-(bromomethyl)alk-2-enoates 2, which were transformed regioselectively into N-substituted methyl (E)-2-(aminomethyl)alk-2-enoates 3 (SN2 reaction
