13712-78-2

Basic information

• Product Name: 7-METHYLGRAMINE
• Synonyms: 3-(DIMETHYLAMINOMETHYL)-7-METHYLINDOLE;7-METHYLGRAMINE;3-((dimethylamino)methyl)-7-methyl-indol;Indole, 3-((dimethylamino)methyl)-7-methyl-
• CAS NO: 13712-78-2
• Molecular Formula: C12H16N2
• Molecular Weight: 188.27
• Product Categories: Indoles and derivatives
• Mol File: 13712-78-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 306.5 °C at 760 mmHg
• Flash Point: 139.2 °C
• Appearance: /
• Density: 1.077 g/cm³
• Vapor Pressure: 0.000768mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHYLGRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLGRAMINE(13712-78-2)
• EPA Substance Registry System: 7-METHYLGRAMINE(13712-78-2)

Safety Data

• Hazardous Substances Data: 13712-78-2(Hazardous Substances Data)

Usage

General Description

7-Methylgramine is a chemical compound with potential pharmacological properties. It is a natural alkaloid compound derived from the plant Senecio scandens, commonly known as English groundsel. Studies have shown that 7-Methylgramine exhibits a variety of biological activities, including anti-inflammatory, antioxidant, and potential neuroprotective effects. It has also been found to have inhibitory effects on acetylcholinesterase, suggesting potential use in the treatment of neurodegenerative diseases such as Alzheimer's. Additionally, 7-Methylgramine has shown promise as a potential lead compound for the development of novel therapeutic agents for various medical conditions. However, further research is needed to fully elucidate its pharmacological properties and potential clinical applications.

InChI:InChI=1/C12H16N2/c1-9-5-4-6-11-10(8-14(2)3)7-13-12(9)11/h4-7,13H,8H2,1-3H3

Upstream product

• 933-67-5 7-methyl-1H-indole 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 858232-97-0 2-(7-methyl-1H-indol-3-yl)acetonitrile 

Relevant articles and documents

I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.

Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction's synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations.