137145-76-7Relevant academic research and scientific papers
Selective mono- and 1,4-di-N-alkylations of 1,4,7,10-tetraazacyclododecane
Li, Zhi,Undheim, Kjell
, p. 1247 - 1253 (2007/10/03)
General methods for selective N-alkylations of the macrocycle 1,4,7,10-tetraazacyclododecane have been developed. The N-monoalkylation proceeds via a cyclic guanidinium derivative, and the rcgioseleclive 1,4-N,N-dialkylation via a cyclic amidinium derivative. All transformations were high yield reactions. Acta Chemica Scandinavica 1998.
Highly regioselective access to 7-substituted 1,4,7,10-tetraazacyclododecane-1-carbaldehyde derivatives: synthetic aspects and NMR elucidation of the structures. X-Ray crystal structures of 7-triphenylmethyl-1,4,7,10-tetraazacyclododecane-1-carbaldehyde and ...
Anelli, Pier Lucio,Calabi, Luisella,Dapporto, Paolo,Murru, Marcella,Paleari, Lino,et al.
, p. 2995 - 3004 (2007/10/03)
7-Substituted 1,4,7,10-tetraazacyclododecane-1-carbaldehydes have been prepared through the ring opening of orthoamide protected intermediates which, in turn, were obtained by reaction of mono N-substituted 1,4,7,10-tetraazacyclododecane derivatives with dimethylformamide diethyl acetal.Orthoamide ring opening occurs under mild reaction conditions and is highly regiospecific.A number of mono- and bi-dimensional NMR experiments have been performed to assign unambiguously the structure of the opened compounds.The regiochemistry of such compounds has also been confirmed by elucidation of the solid-state structure of 7-triphenylmethyl-1,4,7,10-tetraazacyclododecane-1-carbaldehyde by X-ray crystallography.The crystal structure of 7-triphenylmethyloctahydro-5H,9bH-2a,4a,7,9a-tetraazacyclooctapentalene has also been determined.
Intermediates for chelating agents with prefixed symmetry and process for their preparation
-
, (2008/06/13)
The preparation of compounds of formula (I), wherein R and R1 have the meanings specified in claim 1, is disclosed compounds (I) are useful intermediates for the preparation of chelating agents.
