137146-09-9Relevant articles and documents
Triethylamine Hydroiodide as a Bifunctional Catalyst for the Solvent-Free Synthesis of 2-Oxazolidinones
Nishiyori, Ryuichi,Okuno, Ken,Shirakawa, Seiji
, p. 4937 - 4941 (2020/07/30)
Among the wide variety of heterocycles, 2-oxazolidinones are recognized as some of the most important heterocyclic compounds in medicinal chemistry. Therefore, the development of a practical method for their synthesis would be an important development. He
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
Brnardic, Edward J.,Fraley, Mark E.,Garbaccio, Robert M.,Layton, Mark E.,Sanders, John M.,Culberson, Chris,Jacobson, Marlene A.,Magliaro, Brian C.,Hutson, Pete H.,O'Brien, Julie A.,Huszar, Sarah L.,Uslaner, Jason M.,Fillgrove, Kerry L.,Tang, Cuyue,Kuo, Yuhsin,Sur, Sylvie M.,Hartman, George D.
scheme or table, p. 3129 - 3133 (2010/07/20)
Hit to lead optimization of (5R)-5-hexyl-3-phenyl-1,3-oxazolidin-2-one as a positive allosteric modulator of mGluR2 is described. Improvements in potency and metabolic stability were achieved through SAR on both ends of the oxazolidinone. An optimized lea
Selective Formation of α-Cleavage Cycloadduct of Oxirane with Heterocumulene Promoted by High-Coordinated Trialkyltin Complexes
Yano, Katsunori,Amishiro, Nobuyoshi,Baba, Akio,Matsuda, Haruo
, p. 2661 - 2667 (2007/10/02)
In the reaction of monosubstituted oxiranes and heterocumulenes, trialkyltin iodides coordinated by phosphine oxides effectively catalyzed the formation of heterocyles via cleavage at the substituted site in the oxirane ring, while other types of organotin complexes or noncomplexed organotin iodides promoted selective cleavage at the opposite site.A mechanistic investigation demonstrated that the coordination of phophine oxide promotes the reverse reaction of the oxirane-ring cleavage leading to the predominant formation of α-cleavage cycloadducts.