137156-41-3 Usage
General Description
Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate, also known as EtOH-THC, is a chemical compound with the molecular formula C6H7N3O4. It is a derivative of 1,2,3-triazole and is widely used in organic synthesis and medicinal chemistry. Ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate is characterized by its triazole ring structure and carboxylic acid group, which makes it a versatile building block in the synthesis of pharmaceuticals and other organic compounds. It has been studied for its potential anti-inflammatory and anticancer properties, and its derivatives have shown promising biological activities. EtOH-THC is typically synthesized through the reaction of ethyl acetoacetate with sodium azide and subsequent hydrolysis and decarboxylation.
Check Digit Verification of cas no
The CAS Registry Mumber 137156-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,1,5 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 137156-41:
(8*1)+(7*3)+(6*7)+(5*1)+(4*5)+(3*6)+(2*4)+(1*1)=123
123 % 10 = 3
So 137156-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3O3/c1-2-11-5(9)4-3-8(10)7-6-4/h3,10H,2H2,1H3
137156-41-3Relevant articles and documents
Synthesis and application of a novel coupling reagent, ethyl 1-hydroxy- 1H-1,2,3-triazole-4-carboxylate
Jiang, Lu,Davison, Amanda,Tennant, George,Ramage, Robert
, p. 14233 - 14254 (2007/10/03)
An optimal coupling reagent, ethyl 1-hydroxy-1H-1,2,3-triazole-4- carboxylate (HOCt), has been designed and synthesised for application to solid phase peptide synthesis using Fmoc chemistry. It is used in combination with carbodiimide reagents, has very high coupling efficiency, and does not absorb at 302nm, thus allowing real-time monitoring of each coupling cycle. Its applications in the synthesis of endothelin analogues and difficult sequences are also discussed.
