14762-48-2

Upstream product

• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 62-53-3 aniline 

Downstream Products

• 151914-79-3 methyl 1-(3-tert-butyl-1H-pyrazol-5-yl)-1H-1,2,3-triazole-4-carboxylate 
• 92029-41-9 ethyl 2-(4-methylphenyl)-1,3-oxazole-4-carboxylate 
• 10200-43-8 2-methyl-4-carbethoxy-1,3-oxazole 
• 502640-48-4 1-(4-hydroxy-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 4915-97-3 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 142841-03-0 2-(2-Hydroxy-2-phenyl-ethyl)-oxazole-4-carboxylic acid ethyl ester 
• 142841-09-6 2-(1-Hydroxy-cyclohexylmethyl)-oxazole-4-carboxylic acid ethyl ester 
• 142841-04-1 2-((E)-2-Hydroxy-4-phenyl-but-3-enyl)-oxazole-4-carboxylic acid ethyl ester 
• 142841-10-9 2-(2-Hydroxy-2-phenyl-propyl)-oxazole-4-carboxylic acid ethyl ester 
• 142841-11-0 2-((E)-2-Hydroxy-2-methyl-4-phenyl-but-3-enyl)-oxazole-4-carboxylic acid ethyl ester 
• 614-98-2 ethyl 3-furancarboxylate 
• 33004-90-9 ethyl 2-phenylfuran-4-carboxylate 
• 1415476-16-2 ethyl 5-(4-(dimethylamino)phenyl)furan-3-carboxylate 
• 1415476-22-0 ethyl 5-(2-formylphenyl)furan-3-carboxylate 

Relevant academic research and scientific papers

40. Diazoaldehyde chemistry: Part 3. Synthesis of 4-acyl-1H-1,2,3-triazole derivatives

Ten new α -diazo-β-oxoaldehydes were condensed with aniline, ammonia, hydroxylamine, and semicarbazide to yield new 4-acyl-(1-substituted)-1H-1,2,3-triazoles in moderate-to-good yields. The method is simple and regiospecific. The latter feature makes this method superior to the widely used acylacetylene + azide approach.

Diazoaldehyde Chemistry. Part 1. Transdiazotization of Acylacetaldehydes in Neutral-to-Acidic Medium. A Direct Approach to the Synthesis of α-Diazo-β-oxoaldehydes

First ever non-deformylating transdiazotization of acylacetaldehydes was achieved: the reactions of 2-azido-1-ethylpyridinium tetrafluoroborate (4) with acylacetaldehydes 3 proceeded partially without deformylation to yield 16 new α-diazo-β-oxoaldehydes 1 along with diazomethyl ketones 2, especially in the presence of NaOAc (Scheme 1, Tables 1 and 2).The product distribution was substituent-dependent and could be correlated quantitatively.This new diazotization reaction appears as an alternative, direct, and more general method for the synthesis of these diazooxoaldehydes. α-Oxocycloalkanecarbaldehydes 5 gave only traces (if any) of α-diazocycloalkanones 7, and rearrangement products 6 were isolated (Scheme 2).Mechanisms of the reactions are discussed (Schemes 4 and 5).