137157-38-1

Basic information

• Product Name: 3',5'-di-O-benzoyl-2'-deoxy-L-N⁶-benzoyladenosine
• CAS NO: 137157-38-1
• Molecular Weight: 563.569
• Mol File: 137157-38-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',5'-di-O-benzoyl-2'-deoxy-L-N⁶-benzoyladenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-di-O-benzoyl-2'-deoxy-L-N⁶-benzoyladenosine(137157-38-1)
• EPA Substance Registry System: 3',5'-di-O-benzoyl-2'-deoxy-L-N⁶-benzoyladenosine(137157-38-1)

Safety Data

• Hazardous Substances Data: 137157-38-1(Hazardous Substances Data)

Upstream product

• 4005-49-6 N-benzoyladenine 
• 31615-99-3 3',5'-dibenzoyl-2'-deoxy-β-L-uridine 

Downstream Products

• 14365-45-8 L-dA 

Relevant articles and documents

L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth

We have demonstrated that herpes simplex 1 (HSV1) thymidine kinase (TK) shows no stereospecificity for D- and L-β-nucleosides. In vitro, L enantiomers are not recognized by human TK, but function as specific substrates for the viral enzyme in the order: L-thymidine (L-T) >> 2'-deoxy- L-guanosine (L-dG) > 2'-deoxy-L-uridine (L-dU) > 2'-deoxy-L-cytidine (L-dC) > 2'-deoxy-L-adenosine (L-dA). HSV1 TK phosphorylates both thymidine enantiomers to their corresponding monophosphates with identical efficiency and the K(i) of L-T (2 μM) is almost identical to the K(m) for the natural substrate D-T (2.8 μM). The L enantiomer reduces the incorporation of exogenous [3H]T into cellular DNA in HeLa TK-/HSV1 TK+ but not in wild-type HeLa cells, without affecting RNA, protein synthesis, cell growth, and viability. L-T markedly reduces HSV1 multiplication in HeLa cells. Our observations could lead to the development of a novel class of antiviral drugs characterized by low toxicity.