1371645-01-0Relevant academic research and scientific papers
Phase transfer catalyzed enantioselective cyclopropanation of 4-nitro-5-styrylisoxazoles
Fiandra, Claudia Del,Piras, Linda,Fini, Francesco,Disetti, Paolo,Moccia, Maria,Adamo, Mauro F. A.
, p. 3863 - 3865 (2012)
Heavily substituted cyclopropane esters were prepared in high yields, complete diastereoselection and high (up to 96%) enantioselectivity. The reaction described herein entailed reacting 4-nitro-5-styrylisoxazoles, a class of cinnamate synthetic equivalent, with 2-bromomalonate esters under the catalysis of 5 mol% of a Cincona derived phase-transfer catalyst. The reaction allowed multi-gram preparation of desired products. The Royal Society of Chemistry 2012.
