1371663-48-7

Upstream product

• 54401-47-7 6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 50-01-1 guanidine hydrochloride 
• 332103-24-9 4-methoxy-benzoic acid-(2-acetyl-4-methoxy-phenyl ester) 
• 100-09-4 4-methoxybenzoic acid 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 

Relevant academic research and scientific papers

Synthesis method of 2-aminopyrimidine antiplatelet compound

The invention discloses a synthesis method of a 2-aminopyrimidine antiplatelet compound, and the synthesis method comprises the following steps: selecting o-hydroxybenzaldehyde A and 2-bromoacetophenone B containing different substituent groups as raw materials, taking nitrogen heterocyclic carbene as a reaction catalyst, synthesizing an intermediate 1,3-diketone compound C of a novel antiplateletdrug under an alkaline condition, then synthesizing a flavonoid compound D under an acidic condition by the 1,3-diketone compound C, and finally generating the end product 2-aminopyrimidine antiplatelet compound E by the flavonoid compound D and guanidine hydrochloride under an alkaline condition. The synthesis method simplifies the original synthesis method from four steps to three steps, greatly simplifies the original synthesis method, thereby effectively reducing the production cost and the price of medicines, and improving the possibility for industrial production.

Assessment of antiplatelet activity of 2-aminopyrimidines

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.