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137178-88-2

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137178-88-2 Usage

Chemical Properties

Brown solid

Check Digit Verification of cas no

The CAS Registry Mumber 137178-88-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,1,7 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 137178-88:
(8*1)+(7*3)+(6*7)+(5*1)+(4*7)+(3*8)+(2*8)+(1*8)=152
152 % 10 = 2
So 137178-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClNO/c7-4-1-2-5(6(8)10)9-3-4/h1-3H

137178-88-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H61760)  5-Bromopyridine-2-carbonyl chloride, tech. 90%   

  • 137178-88-2

  • 5g

  • 979.0CNY

  • Detail
  • Alfa Aesar

  • (H61760)  5-Bromopyridine-2-carbonyl chloride, tech. 90%   

  • 137178-88-2

  • 25g

  • 3900.0CNY

  • Detail

137178-88-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Bromopyridine-2-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 5-Bromo-pyridine-2-carbonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137178-88-2 SDS

137178-88-2Relevant articles and documents

PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF

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Paragraph 0401; 0788-0790, (2020/01/08)

Disclosed herein is a compound of Formula (AIII) or (III), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors

Mizojiri, Ryo,Asano, Moriteru,Tomita, Daisuke,Banno, Hiroshi,Nii, Noriyuki,Sasaki, Masako,Sumi, Hiroyuki,Satoh, Yoshihiko,Yamamoto, Yukiko,Moriya, Takeo,Satomi, Yoshinori,Maezaki, Hironobu

, p. 1098 - 1117 (2018/02/17)

We initiated our structure-activity relationship (SAR) studies for selective ACC1 inhibitors from 1a as a lead compound. SAR studies of bicyclic scaffolds revealed many potent and selective ACC1 inhibitors represented by 1f; however most of them had physicochemical issues, particularly low aqueous solubility and potent CYP inhibition. To address these two issues and improve the druglikeness of this chemical series, we converted the bicyclic scaffold into a monocyclic framework. Ultimately, this lead us to discover a novel monocyclic derivative 1q as a selective ACC1 inhibitor, which showed highly potent and selective ACC1 inhibition as well as acceptable solubility and CYP inhibition profiles. Since compound 1q displayed favorable bioavailability in mouse cassette dosing testing, we conducted in vivo PD studies of this compound. Oral administration of 1q significantly reduced the concentration of malonyl-CoA in HCT-116 xenograft tumors at doses of more than 30 mg/kg. Accordingly, our novel series of selective ACC1 inhibitors represents a set of useful orally available research tools, as well as potential therapeutic agents for cancer and fatty acid related diseases.

IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER

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Paragraph 00262, (2018/04/12)

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

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