137206-97-4 Usage
Uses
Used in Pharmaceutical Research:
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE is used as a research compound for studying the role of PDGFRβ in various cellular processes and diseases. Its high selectivity and potency make it an ideal tool for investigating the molecular mechanisms underlying PDGFRβ-mediated signaling pathways.
Used in Drug Development:
In the pharmaceutical industry, 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE is used as a lead compound for the development of novel therapeutics targeting PDGFRβ. Its selective inhibition of PDGFRβ can potentially be harnessed to develop drugs for the treatment of diseases associated with the overactivation of this receptor, such as certain types of cancer and fibrosis.
Used in Cancer Research:
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE is used as an inhibitor of PDGFRβ in cancer research, particularly for studying its role in tumor growth, angiogenesis, and metastasis. By selectively targeting PDGFRβ, DMPQ 2HCl can help researchers understand the contribution of this receptor to cancer progression and identify potential therapeutic strategies for PDGFRβ-driven malignancies.
Used in Fibrosis Research:
In the field of fibrosis research, 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE is used as a tool to investigate the role of PDGFRβ in the pathogenesis of fibrotic diseases, such as pulmonary fibrosis, kidney fibrosis, and liver fibrosis. Its selective inhibition of PDGFRβ can provide insights into the molecular mechanisms underlying fibrosis development and help identify potential therapeutic targets for these conditions.
Used in Cell Signaling Studies:
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE is used as a cell signaling modulator in various research applications, including the study of PDGFRβ-mediated signaling pathways and their impact on cell proliferation, migration, and survival. Its high selectivity and potency make it a valuable tool for dissecting the complex network of signaling events regulated by PDGFRβ.
Biological Activity
A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
References
1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627
Check Digit Verification of cas no
The CAS Registry Mumber 137206-97-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,0 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 137206-97:
(8*1)+(7*3)+(6*7)+(5*2)+(4*0)+(3*6)+(2*9)+(1*7)=124
124 % 10 = 4
So 137206-97-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
137206-97-4Relevant academic research and scientific papers
A Convenient Synthesis of 3-(4-Pyridinyl)quinolines
Singh, Baldev,Lesher, George Y.
, p. 1453 - 1454 (2007/10/02)
3-(Arylamino)-2-(4-pyridinyl)acroleins 3 prepared by reacting anilines 1 with 3-(dimethylamino)-2-(4-pyridinyl)acrolein (2) were cyclized with phosphorus oxychloride or acetic acid to give 3-(4-pyridinyl)quinolines 4.
