1372133-79-3Relevant academic research and scientific papers
Chiral N-aryl tert-butanesulfinamide-olefin ligands for rhodium-catalyzed asymmetric 1,4-addition of aryl boronic acids to cyclic enones
Yuan, Shuai,Zeng, Qingle,Wang, Jiajun,Zhou, Lihong
, p. 32 - 42 (2021)
Chiral N-aryl sulfinamide-olefins which are readily synthesized via C-N coupling and nucleophilic substitution have been used as chiral ligands, which demonstrate moderate to excellent asymmetric catalytic performance in the rhodium-catalyzed asymmetric 1
Kinetic Resolution of Sulfinamides via Asymmetric N-Allylic Alkylation
Zheng, Gao-Liang,Lu, Chenxi,Cheng, Jin-Pei,Li, Xin
, p. 8499 - 8504 (2021/10/25)
An efficient kinetic resolution of sulfinamides via an asymmetric N-allylic alkylation reaction was realized using hydroquinine as a catalyst under mild conditions. The kinetic resolution of a range of Morita-Baylis-Hillman adducts and N-aryl tert-butylsulfinamides was highly effective. In addition, the synthetic utility of the protocol was demonstrated by a scaled-up reaction. Density functional theory calculations provide convincing evidence for the interpretation of stereoselection.
Palladium-catalyzed C-N cross coupling of sulfinamides and aryl halides
Sun, Xiaofei,Tu, Xingzhao,Dai, Chuan,Zhang, Xiaoping,Zhang, Binbin,Zeng, Qingle
supporting information; experimental part, p. 4454 - 4459 (2012/07/03)
The palladium-catalyzed C-N cross coupling of sulfinamides and aryl halides is reported. In the presence of Pd2(dba)3, tBuXPhos, NaOH, and a small amount of water, the C-N cross coupling of chiral tert-butanesulfinamide and aryl halides was accomplished to give N-aryl tert-butanesulfinamide without racemization, and the coupling of racemic p-toluenesulfinamide smoothly afforded N-aryl p-toluenesulfinamides. 2-Bromopyridine was also suitable for the coupling. Addition of a small amount of water to the catalytic system was of importance to obtain high yields.
