1372173-57-3Relevant academic research and scientific papers
On the Regioselectivity of the Nickel-Catalyzed Insertion of Alkynes into the Carbon-Carbon Bond of Oxetan-3-one
Barday, Manuel,Janot, Christopher,Clare, Daniel,Carr-Knox, Caitlin,Higginson, Bradley,Ho, Kelvin Y. T.,A?ssa, Christophe
, p. 3582 - 3589 (2017/08/16)
The study of the regioselectivity of insertion of unsymmetrical alkynes into the carbon-carbon bond of oxetan-3-one in the presence of a nickel catalyst has revealed a strong directing effect of a 2-thienyl substituent. This effect is larger than those of 2-vinylbenzene, trimethylsilyl, aryl, or 3-thienyl groups.
An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones
Thakur, Ashish,Evangelista, Judah L.,Kumar, Puneet,Louie, Janis
, p. 9951 - 9958 (2015/11/03)
An efficient and convenient procedure that generates the active Ni(0) catalyst in situ from cheap, air stable Ni(II) precursors is developed for the [4 + 2]-cycloaddition of alkynes and 3-azetidinones. The reaction affords useful 3-dehydropiperidinones in
SUBSTITUTED 3-PIPERIDONE COMPOUNDS
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Paragraph 0161; 0181-0182, (2013/03/26)
Described herein are methods for synthesizing substituted 3-piperidone compounds. Notably, substituted 3-piperidones can also be prepared in enantiopure form. The methods may allow for preparation of highly substituted piperidine cores. Also disclosed are
A single step approach to piperidines via ni-catalyzed β-carbon elimination
Kumar, Puneet,Louie, Janis
supporting information; experimental part, p. 2026 - 2029 (2012/06/29)
An easy and expeditious route to substituted piperidines is described. A Ni-phosphine complex was used as catalyst for [4 + 2] cycloaddition of 3-azetidinone and alkynes. The reaction has broad substrate scope and affords piperidines in excellent yields a
Synthesis of enantiopure dehydropiperidinones from α-amino acids and alkynes via azetidin-3-ones
Ishida, Naoki,Yuhki, Tatsuya,Murakami, Masahiro
supporting information; experimental part, p. 3898 - 3901 (2012/09/22)
Chiral dehydropiperidinones were synthesized in enantiopure form from α-amino acids and alkynes via azetidin-3-ones.
Regioselective cycloaddition of 3-azetidinones and 3-oxetanones with alkynes through nickel-catalysed carbon-carbon bond activation
Ho, Kelvin Y. T.,Aissa, Christophe
supporting information; experimental part, p. 3486 - 3489 (2012/05/19)
Get in the ring! The first examples of transition-metal-catalysed C-C bond activation of 3-azetidinones and 3-oxetanones are reported. In the presence of a nickel catalyst and alkynes, a regioselective and high-yielding [4+2] cycloaddition occurs, leading to the formation of pyridinones, pyranones and eventually 4,5-disubstituted 3-hydroxypyridines (see scheme). Copyright
