137225-06-0

Basic information

• Product Name: 2-(M-tolylaMino)isonicotinonitrile
• Synonyms: 2-(M-tolylaMino)isonicotinonitrile
• CAS NO: 137225-06-0
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.24654
• Mol File: 137225-06-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(M-tolylaMino)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(M-tolylaMino)isonicotinonitrile(137225-06-0)
• EPA Substance Registry System: 2-(M-tolylaMino)isonicotinonitrile(137225-06-0)

Safety Data

• Hazardous Substances Data: 137225-06-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(M-tolylamino)isonicotinonitrile is used as a key building block for the synthesis of various medically important compounds. Its unique chemical structure allows for the creation of a wide range of pharmaceuticals with diverse therapeutic applications.
Used as a Chemical Intermediate in Organic Synthesis:
In the field of organic synthesis, 2-(M-tolylamino)isonicotinonitrile serves as a valuable chemical intermediate. Its reactivity and functional groups enable the formation of complex organic molecules, contributing to the advancement of chemical research and the development of novel compounds with potential applications in various industries.

Upstream product

• 29181-50-8 2,4-Dicyanopyridine 
• 108-44-1 1-amino-3-methylbenzene 
• 33252-30-1 2-chloro-4-pyridinenitrile 

Relevant articles and documents

Efficient synthesis of 2-arylamino substituted pyridinyl nitriles by Buchwald-Hartwig amination

Both nitrile and arylamino groups containing pyridine derivatives are synthesized from commercially available nitrile substituted pyridyl chlorides via a palladium-BINAP catalyst (the second generation catalyst for the amination) in moderate to good yields. The mild conditions permit the presence of base sensitive functional groups. Noteably, the halogen atoms linked to the aromatic ring were maintained in the structures of the products under the amination reaction conditions.

Photochemically Induced Electron Transfer from Aniline Derivatives to Pyridine-2,4-dicarbonitrile: Synthetic and Mechanistic Aspects

A study on the photochemically induced electron transfer from substituted aniline donors to a 2,4-dicyanopyridine acceptor permits the synthesis of new amino derivatives of the pyridine and forms the basis of a hypothesis on the mechanism of the reaction and the influence of the substituent on the aniline ring.