137225-34-4Relevant academic research and scientific papers
Design and synthesis of new benzopyrimidinone derivatives: α-amylase inhibitory activity, molecular docking and DFT studies
Chortani, Sarra,Horchani, Mabrouk,Znati, Mansour,Issaoui, Noureddine,Jannet, Hichem Ben,Romdhane, Anis
, (2021/01/25)
New benzopyrimidinone derivatives have been synthesized by reaction of 2-aminobenzamide with different acyl chlorides in good yield and their structures were confirmed by 1H NMR, 13C NMR and mass spectrometry. The newly synthesized c
Synthesis and some reactions of 2-(1-chloroethyl)-3,1-benzoxazin-4(H)-one
Sayed, M A,El-Kafrawy, A F,Soliman, A Y,El-Bassiouny, F A
, p. 980 - 983 (2007/10/02)
2-(1-Chloroethyl)-3,1-benzoxazin-4(H)-one (II) reacts with ammonia to give the corresponding quinazolone (III) which on alkylation provides 3-N-alkyl quinazolones (IVa,b).Quinazolone III undergoes Mannich reaction with formaldehyde to give the Mannich base (V).It also reacts with P2S5 to give quinazole-4-thione (VI).The benzoxazinone II also reacts with hydrazines to give 3-aminoquinazolones (VIIa,b) which undergo condensation with p-chlorobenzaldehyde to afford the schiff base (VIII).Amonolysis of II gives the anilides (XIa,b) which undergo ring closure with Ac2O to give the quinazolone IVb.Reaction of II with P2S5 gives the benzothiazinone (XII) which reacts with benzylamine to give IVb.Reaction of II with hydrocarbons under Friedel Crafts conditions furnishes the phenyl aryl ketone derivatives (XIIIa,b).
