137233-97-7Relevant academic research and scientific papers
METHODS FOR THE SYNTHESIS OF HETEROAROMATIC COMPOUNDS
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Page/Page column 35, (2008/06/13)
Methods of making heteroaromatic compounds comprising a 5- membered ring, and dihydro forms thereof, by a metal catalysed 5-endo-cyclisation of alkynes (acetylenes) are disclosed. The methods involve the use of a catalyst comprising a silver salt, more preferably a silver (I) salt, which is employed as a heterogeneous catalyst for the cyclisation reaction. The methods can produce different types of heteroaromatic compounds and are capable of producing highly substituted products, i.e. products in which the 5-membered ring is disubstituted, trisubstituted or, with further simple reactions, tetrasubstituted. The methods described herein generally the advantages that they use conditions and reagents that are benign, cheap and flexible and amenable to scale up, and in which the only by-product is water.
Cyclization Reactions of Rhodium Carbene Complexes. Effect of Composition and Oxidation State of the Metal
Padwa, Albert,Kassir, Jamal M.,Xu, Simon L.
, p. 1642 - 1652 (2007/10/03)
Treatment of o-(1,7-octadiynyl)benzoyldiazoethane with rhodium(II) octanoate in pentane resulted in a double internal/internal alkyne insertion reaction producing a labile bicyclo[4.1.0]hept-1(7)-ene derivative which readily undergoes a Diels-Alder reacti
Rhodium-Catalyzed Ring-Opening Reaction of Cyclopropenes. Control of Regioselectivity by the Oxidation State of the Metal
Padwa, Albert,Kassir, Jamal M.,Xu, Simon L.
, p. 6971 - 6972 (2007/10/02)
The Rh(II)-catalyzed reaction of unsymmetrically substituted cyclopropenes gives substituted furans derived from cleavage of the less substituted α-bond.In contrast, Rh(I) catalysis results in cleavage of the more substituted α-bond producing a regioisome
