137235-13-3

Basic information

• Product Name: 1-(2,4-DICHLORO-PHENYL)-3-DIMETHYLAMINO-PROPENONE
• Synonyms: 1-(2,4-DICHLOROPHENYL)-3-(DIMETHYLAMINO)-2-PROPEN-1-ONE;1-(2,4-DICHLORO-PHENYL)-3-DIMETHYLAMINO-PROPENONE;(E)-1-(2,4-dichlorophenyl)-3-dimethylamino-prop-2-en-1-one;(E)-1-(2,4-dichlorophenyl)-3-dimethylaminoprop-2-en-1-one;1-(2,4-dichlorophenyl)-3-(dimethylamino)prop-2-en-1-one;1-(2,4-dichlorophenyl)-3-dimethylamino-prop-2-en-1-one;1-(2,4-dichlorophenyl)-3-dimethylaminoprop-2-en-1-one
• CAS NO: 137235-13-3
• Molecular Formula: C₁₁H₁₁Cl₂NO
• Molecular Weight: 244.12
• Mol File: 137235-13-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 342.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• PKA: 6.19±0.70(Predicted)
• CAS DataBase Reference: 1-(2,4-DICHLORO-PHENYL)-3-DIMETHYLAMINO-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-DICHLORO-PHENYL)-3-DIMETHYLAMINO-PROPENONE(137235-13-3)
• EPA Substance Registry System: 1-(2,4-DICHLORO-PHENYL)-3-DIMETHYLAMINO-PROPENONE(137235-13-3)

Safety Data

• Hazardous Substances Data: 137235-13-3(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 

Downstream Products

• 828273-03-6 4-(2,4-dichlorophenyl)pyrimidin-2-amine 
• 709644-85-9 6-(2,4-dichlorophenyl)-3-cyanopyridine-2-(1H)-thione 

Relevant articles and documents

Synthesis and molecular docking studies of novel pyrimidine derivatives as potential antibacterial agents

Abstract: The present work describes the in vitro antibacterial evaluation of some new pyrimidine derivatives. Twenty-two target compounds were designed, synthesized and preliminarily explored for their antimicrobial activities. The antimicrobial assay revealed that some target compounds exhibited significantly inhibitory efficiencies toward bacteria and fungal including drug-resistant pathogens. Compound 7c presented the most potent inhibitory activities against Gram-positive bacteria (e.g., Staphylococcus aureus 4220), Gram-negative bacteria (e.g., Escherichia coli 1924) and the fungus Candida albicans 7535, with an MIC of 2.4?μmol/L. Compound 7c was also the most potent, with MICs of 2.4 or 4.8?μmol/L against four multidrug-resistant, Gram-positive bacterial strains. The toxicity evaluation of the compounds 7c, 10a, 19d and 26b was assessed in human normal liver cells (L02 cells). Molecular docking simulation and analysis suggested that compound 7c has a good interaction with the active cavities of dihydrofolate reductase (DHFR). In vitro enzyme study implied that compound 7c also displayed DHFR inhibition. Graphic abstract: [Figure not available: see fulltext.]

Design, synthesis, and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase inhibitor

Histone deacetylase (HDAC) inhibitors have been identified for the treatment of cancer. Lately, we designed and synthesized a series of substituted N-benzylpyrimidin-2-amine derivatives as potent HDAC inhibitors. In vitro HDAC inhibitory activities and an