137245-80-8

Basic information

• Product Name: trans-2-ethyl-5-phenyl-pent-4-enoic acid
• Synonyms: trans-2-ethyl-5-phenyl-pent-4-enoic acid
• CAS NO: 137245-80-8
• Molecular Weight: 204.269
• Mol File: 137245-80-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-2-ethyl-5-phenyl-pent-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-ethyl-5-phenyl-pent-4-enoic acid(137245-80-8)
• EPA Substance Registry System: trans-2-ethyl-5-phenyl-pent-4-enoic acid(137245-80-8)

Safety Data

• Hazardous Substances Data: 137245-80-8(Hazardous Substances Data)

Upstream product

• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 103-26-4 methyl cinnamate 
• 100-52-7 benzaldehyde 
• 21040-45-9 Cinnamyl acetate 
• 85287-67-8 2,2,6,6-tetramethyl-4-propylidene-3,5-dioxa-2,6-disilaheptane 

Relevant articles and documents

Highly Regio- A nd Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids

Highly regio- A nd enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted ?,?′-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.