137254-02-5 Usage
Description
(S,S)-trans-2-acetamidocyclopentanol is a chemical compound belonging to the class of cyclopentane derivatives. It is a chiral compound with a non-superimposable mirror image, and the specific (S,S)-trans configuration denotes the orientation of the substituents on the cyclopentane ring. The presence of an acetamide group in its structure suggests potential applications in medicinal chemistry and pharmaceuticals. Due to its unique stereochemistry and functional groups, (S,S)-trans-2-acetamidocyclopentanol may exhibit distinct biological activities and interactions, making it a promising candidate for drug development and research in synthetic organic chemistry. Overall, (S,S)-trans-2-acetamidocyclopentanol represents a valuable chemical entity with potential applications in various scientific and industrial fields.
Uses
Used in Pharmaceutical Industry:
(S,S)-trans-2-acetamidocyclopentanol is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique stereochemistry and functional groups allow for the development of new drugs with improved efficacy and selectivity.
Used in Medicinal Chemistry Research:
(S,S)-trans-2-acetamidocyclopentanol is used as a key intermediate in the design and synthesis of novel bioactive molecules. Its specific configuration and functional groups enable the exploration of new chemical space and the discovery of potential therapeutic agents.
Used in Synthetic Organic Chemistry:
(S,S)-trans-2-acetamidocyclopentanol is used as a versatile synthetic building block for the preparation of complex organic molecules. Its unique structural features facilitate the development of innovative synthetic strategies and the construction of diverse molecular architectures.
Used in Drug Development:
(S,S)-trans-2-acetamidocyclopentanol is used as a potential lead compound in drug discovery. Its specific stereochemistry and functional groups may contribute to the development of new therapeutic agents with novel mechanisms of action and improved pharmacological properties.
Used in Chiral Chemistry:
(S,S)-trans-2-acetamidocyclopentanol is used as a chiral reference standard for the determination of enantiomeric purity and the study of stereoselective reactions. Its unique configuration allows for the investigation of stereochemical effects in various chemical and biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 137254-02-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,5 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 137254-02:
(8*1)+(7*3)+(6*7)+(5*2)+(4*5)+(3*4)+(2*0)+(1*2)=115
115 % 10 = 5
So 137254-02-5 is a valid CAS Registry Number.
137254-02-5Relevant articles and documents
Backbone modification of β-hairpin-forming tetrapeptides in asymmetric acyl transfer reactions
Chen, Peng,Qu, Jin
experimental part, p. 2994 - 3004 (2011/07/08)
Synthetic oligopeptides as mimics of enzymes have been increasingly exploited as catalysts for asymmetric reactions, but highly effective oligopeptide catalysts with relatively low molecular weight are still in great demand. In this paper, we showed the conformational engineering of the β-hairpin-forming tetrapeptide 4 which was first reported by Miller's group as the catalyst for the asymmetric acyl transfer reaction of trans-2-(N-acetylamino)cyclohexan-1-ol (krel = 28). Through our backbone modification strategy, thioamide and sulfonamide as the isosteres of amide were introduced in the β-hairpin secondary structure. The thioxo peptides also adopt β-hairpin conformations as the oxopeptide supported by the combined use of NMR, IR, and X-ray techniques. Thioxo tetrapeptide 14 formed a more constrained β-hairpin conformation and therefore delivered much higher enantioselectivity (krel = 109) in the same reaction. Moreover, the examination of the conformational changes of tetrapeptide 8 upon the protonation of the Nπ-methylhistidine moiety provided evidence to explain the variation of its catalytic efficiency in the asymmetric acyl-transfer reaction.
Practical Synthesis of Enantiopure Cyclic 1,2-Amino Alcohols via Catalytic Asymmetric Ring Opening of Meso Epoxides
Schaus, Scott E.,Larrow, Jay F.,Jacobsen, Eric N.
, p. 4197 - 4199 (2007/10/03)
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