1372541-13-3

Basic information

• Product Name: 3-(2-naphthylmethyl)-4-phenyl-1,3-thiazole-2(3H)-thione
• CAS NO: 1372541-13-3
• Molecular Weight: 333.478
• Mol File: 1372541-13-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-naphthylmethyl)-4-phenyl-1,3-thiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-naphthylmethyl)-4-phenyl-1,3-thiazole-2(3H)-thione(1372541-13-3)
• EPA Substance Registry System: 3-(2-naphthylmethyl)-4-phenyl-1,3-thiazole-2(3H)-thione(1372541-13-3)

Safety Data

• Hazardous Substances Data: 1372541-13-3(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 2018-90-8 naphthalen-2-ylmethylamine 
• 70-11-1 α-bromoacetophenone 

Relevant articles and documents

The reaction of carbon disulfide with bromoacetophenone in the presence of primary amines: Synthesis of 3-alkyl-4-phenyl-1,3-thiazole-2(3 H)-thione derivatives

A three-component reaction between a primary amine, carbon disulfide, and bromoacetophenone that affords novel 3-alkyl-4-phenyl-1,3-thiazole-2(3H)-thione derivatives is reported. The reaction sequence consists of an initial nucleophilic addition of primary amines to carbon disulfide, followed by the nucleophilic attack of carbamodithioic acid so obtained to the bromoacetophenone, and then ring closure by intramolecular attack of nitrogen to the carbonyl carbon to afford the products. This cascade reaction sequence represents a rapid and unprecedented route to the described molecules that have biological specifications.